Xanthine oxidase substrate
- Drug is metabolized/inactivated by xanthine oxidase
- XO inhibition can sharply increase exposure
- Azathioprine/6-MP are classic high-risk victims
- Myelosuppression can be life-threatening
- Interaction requires major dose reduction or avoidance
Interaction at a glance
- Drug is metabolized/inactivated by xanthine oxidase
Mechanism
- Drug is metabolized/inactivated by xanthine oxidase
Magnitude / time course
- XO inhibition can sharply increase exposure
Clinical consequence
- Azathioprine/6-MP are classic high-risk victims
- Myelosuppression can be life-threatening
Management
- Interaction requires major dose reduction or avoidance
Self-check
- What is the main clinical risk of Xanthine oxidase substrate?
Myelosuppression can be life-threatening.
- What happens to a xanthine-oxidase substrate when xanthine oxidase is inhibited?
Its exposure can rise sharply.
Drugs in this interaction (2)
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