Verapamil/diltiazem + digoxin — ↑ digoxin
- Non-DHP CCBs slow AV conduction
- They can also raise digoxin exposure
- verapamil often ↑ digoxin ~50–75%
- Bradycardia/AV block + toxicity can result
- Check digoxin level + heart rate
- Dose reduction may be needed
Interaction at a glance
- They can also raise digoxin exposure
- verapamil often ↑ digoxin ~50–75%
- Dose reduction may be needed
Mechanism
- Non-DHP CCBs slow AV conduction
Magnitude / time course
- They can also raise digoxin exposure
- verapamil often ↑ digoxin ~50–75%
Clinical consequence
- Bradycardia/AV block + toxicity can result
Monitoring
- Check digoxin level + heart rate
- Dose reduction may be needed
Self-check
- What should be monitored with Verapamil/diltiazem + digoxin?
digoxin level + heart rate.
- What is the main clinical risk of Verapamil/diltiazem + digoxin?
Bradycardia/AV block + toxicity can result.
Drugs in this interaction (3)
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