UGT2B7 inhibitor
- Inhibits UGT2B7 glucuronidation
- UGT2B7 substrate exposure can rise
- Toxicity risk rises for narrow-index victims
- Magnitude is drug- and isoform-specific
- Consider alternative clearance pathways
Interaction at a glance
- Inhibits UGT2B7 glucuronidation
Magnitude / time course
- Inhibits UGT2B7 glucuronidation
- UGT2B7 substrate exposure can rise
Exposure modifiers
- Magnitude is drug- and isoform-specific
- Consider alternative clearance pathways
Clinical consequence
- Toxicity risk rises for narrow-index victims
Self-check
- What is the main clinical risk of UGT2B7 inhibitor?
Toxicity risk rises for narrow-index victims.
- What usually happens to a sensitive UGT2B7 substrate when a UGT2B7 inhibitor is added?
Its exposure increases.
Drugs in this interaction (2)
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