UGT2B7 inhibitor
- Inhibits UGT2B7 glucuronidation
- UGT2B7 substrate exposure can rise
- Toxicity risk rises for narrow-index victims
- Magnitude is drug- and isoform-specific
- Consider alternative clearance pathways
Interaction at a glance
- Inhibits UGT2B7 glucuronidation
Magnitude / time course
- Inhibits UGT2B7 glucuronidation
- UGT2B7 substrate exposure can rise
Exposure modifiers
- Magnitude is drug- and isoform-specific
- Consider alternative clearance pathways
Clinical consequence
- Toxicity risk rises for narrow-index victims
Self-check
- Key risk with UGT2B7 inhibitor?
Toxicity risk rises for narrow-index victims. - How does UGT2B7 inhibition affect sensitive-substrate exposure?
It can rise.
Drugs in this interaction (2)
All interaction examples · Open UGT2B7 inhibitor in the interactive console ↗