UGT1A1 inhibitor
- Inhibits UGT1A1 glucuronidation
- UGT1A1 substrate exposure can rise
- Toxicity risk rises for narrow-index victims
- Magnitude is drug- and isoform-specific
- Consider alternative clearance pathways
Interaction at a glance
- Inhibits UGT1A1 glucuronidation
Magnitude / time course
- Inhibits UGT1A1 glucuronidation
- UGT1A1 substrate exposure can rise
Exposure modifiers
- Magnitude is drug- and isoform-specific
- Consider alternative clearance pathways
Clinical consequence
- Toxicity risk rises for narrow-index victims
Self-check
- What is the main clinical risk of UGT1A1 inhibitor?
Toxicity risk rises for narrow-index victims.
- What usually happens to a sensitive UGT1A1 substrate when a UGT1A1 inhibitor is added?
Its exposure increases.
Drugs in this interaction (3)
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