UGT1A1 inhibitor
- Inhibits UGT1A1 glucuronidation
- UGT1A1 substrate exposure can rise
- Toxicity risk rises for narrow-index victims
- Magnitude is drug- and isoform-specific
- Consider alternative clearance pathways
Interaction at a glance
- Inhibits UGT1A1 glucuronidation
Magnitude / time course
- Inhibits UGT1A1 glucuronidation
- UGT1A1 substrate exposure can rise
Exposure modifiers
- Magnitude is drug- and isoform-specific
- Consider alternative clearance pathways
Clinical consequence
- Toxicity risk rises for narrow-index victims
Self-check
- Key risk with UGT1A1 inhibitor?
Toxicity risk rises for narrow-index victims. - How does UGT1A1 inhibition affect sensitive-substrate exposure?
It can rise.
Drugs in this interaction (3)
All interaction examples · Open UGT1A1 inhibitor in the interactive console ↗