TPMT substrate
- Thiopurine metabolism depends partly on TPMT
- Low TPMT activity shifts toward active metabolites
- Standard doses can cause severe marrow suppression
- Azathioprine/6-MP are classic substrates
- TPMT testing does not replace CBC monitoring
Interaction at a glance
- Thiopurine metabolism depends partly on TPMT
Mechanism
- Thiopurine metabolism depends partly on TPMT
Mechanism / modifiers
- Low TPMT activity shifts toward active metabolites
- Azathioprine/6-MP are classic substrates
Monitoring
- Standard doses can cause severe marrow suppression
- TPMT testing does not replace CBC monitoring
Self-check
- Which drugs are classic TPMT substrates?
Azathioprine and 6-MP. - Does TPMT testing replace CBC monitoring?
No.
Drugs in this interaction (2)
All interaction examples · Open TPMT substrate in the interactive console ↗