TPMT substrate
- Thiopurine metabolism depends partly on TPMT
- Low TPMT activity shifts toward active metabolites
- Standard doses can cause severe marrow suppression
- Azathioprine/6-MP are classic substrates
- TPMT testing does not replace CBC monitoring
Interaction at a glance
- Thiopurine metabolism depends partly on TPMT
Mechanism
- Thiopurine metabolism depends partly on TPMT
Mechanism / modifiers
- Low TPMT activity shifts toward active metabolites
- Azathioprine/6-MP are classic substrates
Monitoring
- Standard doses can cause severe marrow suppression
- TPMT testing does not replace CBC monitoring
Self-check
- What does “TPMT substrate” mean?
Thiopurine metabolism depends partly on TPMT.
Drugs in this interaction (2)
All interaction examples · Open the interactive console ↗
