SLCO1B1 phenotype-sensitive
- OATP1B1 genetics alter hepatic drug uptake
- Reduced-function SLCO1B1 raises some statin levels
- Simvastatin myopathy risk is the classic example
- Drug choice/dose can be genotype-guided
- Effect differs greatly by statin
Interaction at a glance
- OATP1B1 genetics alter hepatic drug uptake
Mechanism
- OATP1B1 genetics alter hepatic drug uptake
Clinical consequence
- Simvastatin myopathy risk is the classic example
Management
- Reduced-function SLCO1B1 raises some statin levels
- Drug choice/dose can be genotype-guided
Mechanism / modifiers
- Effect differs greatly by statin
Self-check
- Which statin toxicity is the classic SLCO1B1 example?
Simvastatin myopathy. - Does the SLCO1B1 effect vary by statin?
Yes; greatly.
Drugs in this interaction (7)
All interaction examples · Open SLCO1B1 phenotype-sensitive in the interactive console ↗