Renal clearance (glomerular filtration)
- Unbound drug is filtered at the glomerulus
- Filtration falls as GFR falls
- High protein binding limits filtered fraction
- Dose adjustment may track kidney function
- Active secretion/reabsorption can add to net clearance
Interaction at a glance
- Unbound drug is filtered at the glomerulus
Mechanism
- Unbound drug is filtered at the glomerulus
- Filtration falls as GFR falls
Magnitude / time course
- High protein binding limits filtered fraction
- Active secretion/reabsorption can add to net clearance
Management
- Dose adjustment may track kidney function
Self-check
- Which drug fraction undergoes glomerular filtration?
Unbound drug. - How does high protein binding affect glomerular filtration?
Limits the filtered fraction.
Drugs in this interaction (11)
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