OCT2 substrate
- Substrate of OCT2
- OCT2 renal organic-cation transporter
- Transporter changes can alter exposure/distribution
- Inhibitors may raise or lower AUC by transporter role
- Kidney/liver/GI location determines direction
Interaction at a glance
- Substrate of OCT2
- OCT2 renal organic-cation transporter
Mechanism
- Substrate of OCT2
- OCT2 renal organic-cation transporter
Magnitude / time course
- Inhibitors may raise or lower AUC by transporter role
- Kidney/liver/GI location determines direction
Exposure modifiers
- Transporter changes can alter exposure/distribution
Self-check
- What transport role and location characterize OCT2?
Renal organic-cation transporter. - Can changes in OCT2 affect drug distribution as well as exposure?
Yes.
Drugs in this interaction (5)
All interaction examples · Open OCT2 substrate in the interactive console ↗