OCT2 substrate
- Substrate of OCT2
- OCT2 renal organic-cation transporter
- Transporter changes can alter exposure/distribution
- Inhibitors may raise or lower AUC by transporter role
- Kidney/liver/GI location determines direction
Interaction at a glance
- Substrate of OCT2
- OCT2 renal organic-cation transporter
Mechanism
- Substrate of OCT2
- OCT2 renal organic-cation transporter
Magnitude / time course
- Inhibitors may raise or lower AUC by transporter role
- Kidney/liver/GI location determines direction
Exposure modifiers
- Transporter changes can alter exposure/distribution
Self-check
- What does “OCT2 substrate” mean?
Substrate of OCT2.
Drugs in this interaction (5)
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