OATP1B3 inhibitor
- Inhibits OATP1B3
- OATP1B3 hepatic uptake transporter
- Can change exposure of transporter substrates
- Direction depends on uptake vs efflux location
- Clinically important for selected narrow-index drugs
Interaction at a glance
- Inhibits OATP1B3
- OATP1B3 hepatic uptake transporter
Mechanism
- Inhibits OATP1B3
- OATP1B3 hepatic uptake transporter
Magnitude / time course
- Can change exposure of transporter substrates
Mechanism / modifiers
- Direction depends on uptake vs efflux location
- Clinically important for selected narrow-index drugs
Self-check
- What determines an OATP1B3 inhibitor’s exposure-effect direction?
Uptake versus efflux location. - What transport role and location characterize OATP1B3?
Hepatic uptake transporter.
Drugs in this interaction (5)
All interaction examples · Open OATP1B3 inhibitor in the interactive console ↗