OATP1B1 substrate
- Substrate of OATP1B1
- OATP1B1 hepatic uptake transporter
- Transporter changes can alter exposure/distribution
- Inhibitors may raise or lower AUC by transporter role
- Kidney/liver/GI location determines direction
Interaction at a glance
- Substrate of OATP1B1
- OATP1B1 hepatic uptake transporter
Mechanism
- Substrate of OATP1B1
- OATP1B1 hepatic uptake transporter
Magnitude / time course
- Inhibitors may raise or lower AUC by transporter role
- Kidney/liver/GI location determines direction
Exposure modifiers
- Transporter changes can alter exposure/distribution
Self-check
- What does “OATP1B1 substrate” mean?
Substrate of OATP1B1.
Drugs in this interaction (8)
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