OATP1B1 substrate
- Substrate of OATP1B1
- OATP1B1 hepatic uptake transporter
- Transporter changes can alter exposure/distribution
- Inhibitors may raise or lower AUC by transporter role
- Kidney/liver/GI location determines direction
Interaction at a glance
- Substrate of OATP1B1
- OATP1B1 hepatic uptake transporter
Mechanism
- Substrate of OATP1B1
- OATP1B1 hepatic uptake transporter
Magnitude / time course
- Inhibitors may raise or lower AUC by transporter role
- Kidney/liver/GI location determines direction
Exposure modifiers
- Transporter changes can alter exposure/distribution
Self-check
- What transport role and location characterize OATP1B1?
Hepatic uptake transporter. - Can changes in OATP1B1 affect drug distribution as well as exposure?
Yes.
Drugs in this interaction (8)
All interaction examples · Open OATP1B1 substrate in the interactive console ↗