OATP1B1 inhibitor
- Inhibits OATP1B1
- OATP1B1 hepatic uptake transporter
- Can change exposure of transporter substrates
- Direction depends on uptake vs efflux location
- Clinically important for selected narrow-index drugs
Interaction at a glance
- Inhibits OATP1B1
- OATP1B1 hepatic uptake transporter
Mechanism
- Inhibits OATP1B1
- OATP1B1 hepatic uptake transporter
Magnitude / time course
- Can change exposure of transporter substrates
Mechanism / modifiers
- Direction depends on uptake vs efflux location
- Clinically important for selected narrow-index drugs
Self-check
- What usually happens to a sensitive OATP1B1 substrate when a OATP1B1 inhibitor is added?
Its exposure increases.
Drugs in this interaction (6)
All interaction examples · Open the interactive console ↗
