OAT1 inhibitor
- Inhibits OAT1
- OAT1 renal organic-anion transporter
- Can change exposure of transporter substrates
- Direction depends on uptake vs efflux location
- Clinically important for selected narrow-index drugs
Interaction at a glance
- Inhibits OAT1
- OAT1 renal organic-anion transporter
Mechanism
- Inhibits OAT1
- OAT1 renal organic-anion transporter
Magnitude / time course
- Can change exposure of transporter substrates
Mechanism / modifiers
- Direction depends on uptake vs efflux location
- Clinically important for selected narrow-index drugs
Self-check
- What transport role and location characterize OAT1?
Renal organic-anion transporter. - What determines an inhibitor’s effect direction for transporter substrates?
Uptake versus efflux location.
Drugs in this interaction (1)
All interaction examples · Open OAT1 inhibitor in the interactive console ↗