OAT1 inhibitor
- Inhibits OAT1
- OAT1 renal organic-anion transporter
- Can change exposure of transporter substrates
- Direction depends on uptake vs efflux location
- Clinically important for selected narrow-index drugs
Interaction at a glance
- Inhibits OAT1
- OAT1 renal organic-anion transporter
Mechanism
- Inhibits OAT1
- OAT1 renal organic-anion transporter
Magnitude / time course
- Can change exposure of transporter substrates
Mechanism / modifiers
- Direction depends on uptake vs efflux location
- Clinically important for selected narrow-index drugs
Self-check
- What does “OAT1 inhibitor” mean?
Inhibits OAT1.
Drugs in this interaction (1)
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