NUDT15 phenotype-sensitive
- NUDT15 activity affects thiopurine toxicity
- Reduced-function variants raise active thioguanine burden
- Profound leukopenia can occur at standard doses
- Genotype-guided dose reduction may be necessary
- Especially important in some ancestry groups
Interaction at a glance
- NUDT15 activity affects thiopurine toxicity
Mechanism
- Especially important in some ancestry groups
Clinical consequence
- NUDT15 activity affects thiopurine toxicity
Management
- Reduced-function variants raise active thioguanine burden
- Profound leukopenia can occur at standard doses
- Genotype-guided dose reduction may be necessary
Self-check
- What do reduced-function NUDT15 variants increase?
Active thioguanine burden. - What can occur at standard thiopurine doses with NUDT15 susceptibility?
Profound leukopenia.
Drugs in this interaction (2)
All interaction examples · Open NUDT15 phenotype-sensitive in the interactive console ↗