NUDT15 phenotype-sensitive
- NUDT15 activity affects thiopurine toxicity
- Reduced-function variants raise active thioguanine burden
- Profound leukopenia can occur at standard doses
- Genotype-guided dose reduction may be necessary
- Especially important in some ancestry groups
Interaction at a glance
- NUDT15 activity affects thiopurine toxicity
Mechanism
- Especially important in some ancestry groups
Clinical consequence
- NUDT15 activity affects thiopurine toxicity
Management
- Reduced-function variants raise active thioguanine burden
- Profound leukopenia can occur at standard doses
- Genotype-guided dose reduction may be necessary
Self-check
- What is the main clinical risk of NUDT15 phenotype-sensitive?
NUDT15 activity affects thiopurine toxicity.
Drugs in this interaction (2)
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