Mirtazapine + clonidine/guanfacine — alpha-2 opposition
- Mirtazapine blocks central alpha-2 receptors
- Clonidine/guanfacine stimulate alpha-2
- Pharmacologic effects can oppose
- BP control/sedation effects may change
- Classic concern: clonidine + mirtazapine
Interaction at a glance
- Mirtazapine + clonidine/guanfacine — alpha-2 opposition
Mechanism
- Mirtazapine blocks central alpha-2 receptors
- Clonidine/guanfacine stimulate alpha-2
Mechanism / modifiers
- Pharmacologic effects can oppose
- Classic concern: clonidine + mirtazapine
Mechanism / exceptions
- BP control/sedation effects may change
Self-check
- What can change when mirtazapine is combined with clonidine/guanfacine?
BP control and sedation effects.
- Why can mirtazapine oppose clonidine/guanfacine?
It blocks central alpha-2 receptors they stimulate.
Drugs in this interaction (3)
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