Metabolism (CYP-independent)

Major clearance does not depend on CYP enzymes
Hydrolysis, conjugation or renal pathways may dominate
CYP inducer/inhibitor DDIs are less central
Other transporters/enzymes can still cause interactions
“CYP-independent” does not mean interaction-free

Interaction at a glance

Major clearance does not depend on CYP enzymes

Magnitude / time course

Major clearance does not depend on CYP enzymes
CYP inducer/inhibitor DDIs are less central

Mechanism

Other transporters/enzymes can still cause interactions
“CYP-independent” does not mean interaction-free

Mechanism / modifiers

Hydrolysis, conjugation or renal pathways may dominate

Self-check

Which pathways may dominate CYP-independent clearance?
Hydrolysis, conjugation or renal pathways.
Does CYP-independent metabolism mean interaction-free?
No.

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