MATE2-K substrate
- Substrate of MATE2-K
- MATE2-K renal exporter
- Transporter changes can alter exposure/distribution
- Inhibitors may raise or lower AUC by transporter role
- Kidney/liver/GI location determines direction
Interaction at a glance
- Substrate of MATE2-K
- MATE2-K renal exporter
Mechanism
- Substrate of MATE2-K
- MATE2-K renal exporter
Magnitude / time course
- Inhibitors may raise or lower AUC by transporter role
- Kidney/liver/GI location determines direction
Exposure modifiers
- Transporter changes can alter exposure/distribution
Self-check
- What transport role and location characterize MATE2-K?
Renal exporter. - Can changes in MATE2-K affect drug distribution as well as exposure?
Yes.
Drugs in this interaction (2)
All interaction examples · Open MATE2-K substrate in the interactive console ↗