MATE1 substrate
- Substrate of MATE1
- MATE1 renal/hepatic exporter
- Transporter changes can alter exposure/distribution
- Inhibitors may raise or lower AUC by transporter role
- Kidney/liver/GI location determines direction
Interaction at a glance
- Substrate of MATE1
- MATE1 renal/hepatic exporter
Mechanism
- Substrate of MATE1
- MATE1 renal/hepatic exporter
Magnitude / time course
- Inhibitors may raise or lower AUC by transporter role
- Kidney/liver/GI location determines direction
Exposure modifiers
- Transporter changes can alter exposure/distribution
Self-check
- What does “MATE1 substrate” mean?
Substrate of MATE1.
Drugs in this interaction (3)
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