Ionization (amphoteric)
- Molecule has both acidic and basic groups
- Net charge changes with environmental pH
- Solubility/permeability can vary with pH
- Ion trapping may occur across pH gradients
- pKa—not the label alone—predicts behavior
Interaction at a glance
- Molecule has both acidic and basic groups
Mechanism
- Molecule has both acidic and basic groups
- Net charge changes with environmental pH
Mechanism / modifiers
- Solubility/permeability can vary with pH
Mechanism / exceptions
- Ion trapping may occur across pH gradients
- pKa—not the label alone—predicts behavior
Self-check
- What may occur across pH gradients with amphoteric drugs?
Ion trapping. - What predicts amphoteric-drug behavior better than the label alone?
pKa.
Drugs in this interaction (9)
All interaction examples · Open Ionization (amphoteric) in the interactive console ↗