Ionization (amphoteric)
- Molecule has both acidic and basic groups
- Net charge changes with environmental pH
- Solubility/permeability can vary with pH
- Ion trapping may occur across pH gradients
- pKa—not the label alone—predicts behavior
Interaction at a glance
- Molecule has both acidic and basic groups
Mechanism
- Molecule has both acidic and basic groups
- Net charge changes with environmental pH
Mechanism / modifiers
- Solubility/permeability can vary with pH
Mechanism / exceptions
- Ion trapping may occur across pH gradients
- pKa—not the label alone—predicts behavior
Self-check
- What does “Ionization (amphoteric)” indicate?
Ion trapping may occur across pH gradients.
Drugs in this interaction (9)
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