Hepatic clearance (predominant)
- Liver is the major route of elimination
- Hepatic metabolism and/or biliary excretion dominate
- Liver disease can increase exposure
- CYP/transporter DDIs may be clinically important
- Renal function may matter less—but not necessarily zero
Interaction at a glance
- Liver is the major route of elimination
Mechanism
- Hepatic metabolism and/or biliary excretion dominate
- CYP/transporter DDIs may be clinically important
Magnitude / time course
- Liver disease can increase exposure
Mechanism / modifiers
- Liver is the major route of elimination
- Renal function may matter less—but not necessarily zero
Self-check
- Does predominant hepatic clearance make renal function irrelevant?
No; its impact may be lower, but not necessarily zero.
- How can liver disease affect a predominantly hepatically cleared drug?
Increase exposure.
All interaction examples · Open the interactive console ↗