Hepatic clearance (predominant)
- Liver is the major route of elimination
- Hepatic metabolism and/or biliary excretion dominate
- Liver disease can increase exposure
- CYP/transporter DDIs may be clinically important
- Renal function may matter less—but not necessarily zero
Interaction at a glance
- Liver is the major route of elimination
Mechanism
- Hepatic metabolism and/or biliary excretion dominate
- CYP/transporter DDIs may be clinically important
Magnitude / time course
- Liver disease can increase exposure
Mechanism / modifiers
- Liver is the major route of elimination
- Renal function may matter less—but not necessarily zero
Self-check
- What does “Hepatic clearance (predominant)” mean?
Liver is the major route of elimination.
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