DPYD substrate
- Drug is catabolized by dihydropyrimidine dehydrogenase
- 5-FU/capecitabine pathway is the key context
- Low DPD activity can cause massive exposure
- DPYD genetics can therefore change safe dose
- Toxicity can be early and life-threatening
Interaction at a glance
- Drug is catabolized by dihydropyrimidine dehydrogenase
Mechanism
- Drug is catabolized by dihydropyrimidine dehydrogenase
- 5-FU/capecitabine pathway is the key context
Clinical consequence
- Toxicity can be early and life-threatening
Management
- Low DPD activity can cause massive exposure
- DPYD genetics can therefore change safe dose
Self-check
- What is the main clinical risk of DPYD substrate?
Toxicity can be early and life-threatening.
Drugs in this interaction (2)
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