DPYD substrate
- Drug is catabolized by dihydropyrimidine dehydrogenase
- 5-FU/capecitabine pathway is the key context
- Low DPD activity can cause massive exposure
- DPYD genetics can therefore change safe dose
- Toxicity can be early and life-threatening
Interaction at a glance
- Drug is catabolized by dihydropyrimidine dehydrogenase
Mechanism
- Drug is catabolized by dihydropyrimidine dehydrogenase
- 5-FU/capecitabine pathway is the key context
Clinical consequence
- Toxicity can be early and life-threatening
Management
- Low DPD activity can cause massive exposure
- DPYD genetics can therefore change safe dose
Self-check
- Key risk with DPYD substrate?
Toxicity can be early and life-threatening. - Which drug pathway is the key DPD context?
5-FU/capecitabine.
Drugs in this interaction (2)
All interaction examples · Open DPYD substrate in the interactive console ↗