DPYD phenotype-sensitive
- DPD activity strongly affects fluoropyrimidine clearance
- Reduced-function DPYD variants raise toxicity risk
- Severe mucositis, diarrhea + myelosuppression can occur
- Genotype/phenotype-guided dosing may be needed
- Complete deficiency can make standard dosing dangerous
Interaction at a glance
- DPD activity strongly affects fluoropyrimidine clearance
Magnitude / time course
- DPD activity strongly affects fluoropyrimidine clearance
- Complete deficiency can make standard dosing dangerous
Clinical consequence
- Reduced-function DPYD variants raise toxicity risk
- Severe mucositis, diarrhea + myelosuppression can occur
Mechanism
- Genotype/phenotype-guided dosing may be needed
Self-check
- What is the main clinical risk of DPYD phenotype-sensitive?
Reduced-function DPYD variants raise toxicity risk.
Drugs in this interaction (2)
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