DPYD phenotype-sensitive
- DPD activity strongly affects fluoropyrimidine clearance
- Reduced-function DPYD variants raise toxicity risk
- Severe mucositis, diarrhea + myelosuppression can occur
- Genotype/phenotype-guided dosing may be needed
- Complete deficiency can make standard dosing dangerous
Interaction at a glance
- DPD activity strongly affects fluoropyrimidine clearance
Magnitude / time course
- DPD activity strongly affects fluoropyrimidine clearance
- Complete deficiency can make standard dosing dangerous
Clinical consequence
- Reduced-function DPYD variants raise toxicity risk
- Severe mucositis, diarrhea + myelosuppression can occur
Mechanism
- Genotype/phenotype-guided dosing may be needed
Self-check
- Key risk with DPYD phenotype-sensitive?
Reduced-function DPYD variants raise toxicity risk. - Why can complete DPD deficiency make standard dosing dangerous?
DPD activity strongly affects fluoropyrimidine clearance.
Drugs in this interaction (2)
All interaction examples · Open DPYD phenotype-sensitive in the interactive console ↗