CYP2E1 inhibitor
- Inhibits CYP2E1
- CYP2E1 substrate exposure can rise
- Effect is greatest for sensitive substrates
- Toxicity risk rises with narrow-index victims
- Inhibition often begins faster than induction
- Alcohol and small toxicants are key contexts.
Interaction at a glance
Magnitude / time course
- Inhibits CYP2E1
- CYP2E1 substrate exposure can rise
Mechanism
- Effect is greatest for sensitive substrates
- Inhibition often begins faster than induction
Clinical consequence
- Toxicity risk rises with narrow-index victims
- Alcohol and small toxicants are key contexts.
Self-check
- What is the main clinical risk of CYP2E1 inhibitor?
Toxicity risk rises with narrow-index victims.
- What usually happens to a sensitive CYP2E1 substrate when a CYP2E1 inhibitor is added?
Its exposure increases.
Drugs in this interaction (4)
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