CYP2C8 substrate
- Cleared substantially by CYP2C8
- CYP2C8 inhibitors can raise exposure
- CYP2C8 inducers can lower exposure
- Clinical impact depends on fraction metabolized
- Sensitive substrates show the largest DDIs
- Important for selected drugs; fewer classic DDIs.
Interaction at a glance
- Cleared substantially by CYP2C8
Magnitude / time course
- Cleared substantially by CYP2C8
- CYP2C8 inhibitors can raise exposure
Exposure modifiers
- CYP2C8 inducers can lower exposure
- Clinical impact depends on fraction metabolized
- Sensitive substrates show the largest DDIs
Mechanism
- Important for selected drugs; fewer classic DDIs.
Self-check
- What can happen to CYP2C8-substrate exposure when CYP2C8 is inhibited?
Exposure can rise. - What determines the clinical impact of a CYP2C8-substrate interaction?
Fraction metabolized.
Drugs in this interaction (8)
All interaction examples · Open CYP2C8 substrate in the interactive console ↗