CYP2C8 substrate
- Cleared substantially by CYP2C8
- CYP2C8 inhibitors can raise exposure
- CYP2C8 inducers can lower exposure
- Clinical impact depends on fraction metabolized
- Sensitive substrates show the largest DDIs
- Important for selected drugs; fewer classic DDIs.
Interaction at a glance
- Cleared substantially by CYP2C8
Magnitude / time course
- Cleared substantially by CYP2C8
- CYP2C8 inhibitors can raise exposure
Exposure modifiers
- CYP2C8 inducers can lower exposure
- Clinical impact depends on fraction metabolized
- Sensitive substrates show the largest DDIs
Mechanism
- Important for selected drugs; fewer classic DDIs.
Self-check
- Which pathway substantially clears drugs tagged as CYP2C8 substrate?
CYP2C8.
Drugs in this interaction (8)
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