CYP2C8 inhibitor
- Inhibits CYP2C8
- CYP2C8 substrate exposure can rise
- Effect is greatest for sensitive substrates
- Toxicity risk rises with narrow-index victims
- Inhibition often begins faster than induction
- Important for selected drugs; fewer classic DDIs.
Interaction at a glance
Magnitude / time course
- Inhibits CYP2C8
- CYP2C8 substrate exposure can rise
- Effect is greatest for sensitive substrates
- Inhibition often begins faster than induction
Clinical consequence
- Toxicity risk rises with narrow-index victims
Mechanism
- Important for selected drugs; fewer classic DDIs.
Self-check
- What is the main clinical risk of CYP2C8 inhibitor?
Toxicity risk rises with narrow-index victims.
- What usually happens to a sensitive CYP2C8 substrate when a CYP2C8 inhibitor is added?
Its exposure increases.
Drugs in this interaction (2)
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