CYP2C8 inducer
- Induces CYP2C8 activity/expression
- CYP2C8 substrates usually clear faster
- AUC/effect may fall → treatment failure
- Onset/offset usually takes days
- Strong inducers can affect many co-medications
- Important for selected drugs; fewer classic DDIs.
Interaction at a glance
- Induces CYP2C8 activity/expression
Mechanism
- Induces CYP2C8 activity/expression
- CYP2C8 substrates usually clear faster
- Onset/offset usually takes days
- Strong inducers can affect many co-medications
Clinical consequence
- AUC/effect may fall → treatment failure
Mechanism / modifiers
- Important for selected drugs; fewer classic DDIs.
Self-check
- What usually happens to a sensitive CYP2C8 substrate when a CYP2C8 inducer is added?
Its exposure decreases.
Drugs in this interaction (1)
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