CYP2C8 inducer
- Induces CYP2C8 activity/expression
- CYP2C8 substrates usually clear faster
- AUC/effect may fall → treatment failure
- Onset/offset usually takes days
- Strong inducers can affect many co-medications
- Important for selected drugs; fewer classic DDIs.
Interaction at a glance
- Induces CYP2C8 activity/expression
Mechanism
- Induces CYP2C8 activity/expression
- CYP2C8 substrates usually clear faster
- Onset/offset usually takes days
- Strong inducers can affect many co-medications
Clinical consequence
- AUC/effect may fall → treatment failure
Mechanism / modifiers
- Important for selected drugs; fewer classic DDIs.
Self-check
- How does CYP2C8 induction affect sensitive-substrate exposure?
It may fall. - How long do CYP2C8-induction onset and offset usually take?
Days.
Drugs in this interaction (1)
All interaction examples · Open CYP2C8 inducer in the interactive console ↗