CYP2B6 inhibitor
- Inhibits CYP2B6
- CYP2B6 substrate exposure can rise
- Effect is greatest for sensitive substrates
- Toxicity risk rises with narrow-index victims
- Inhibition often begins faster than induction
- Important for bupropion/efavirenz/methadone.
Interaction at a glance
- Inhibits CYP2B6
Magnitude / time course
- Inhibits CYP2B6
- CYP2B6 substrate exposure can rise
Mechanism
- Effect is greatest for sensitive substrates
- Inhibition often begins faster than induction
- Important for bupropion/efavirenz/methadone.
Clinical consequence
- Toxicity risk rises with narrow-index victims
Self-check
- Key risk with CYP2B6 inhibitor?
Toxicity risk rises with narrow-index victims. - How does CYP2B6 inhibition affect sensitive-substrate exposure?
It can rise.
Drugs in this interaction (4)
All interaction examples · Open CYP2B6 inhibitor in the interactive console ↗