BCRP substrate
- Substrate of BCRP
- breast cancer resistance protein
- Transporter changes can alter exposure/distribution
- Inhibitors may raise or lower AUC by transporter role
- Kidney/liver/GI location determines direction
Interaction at a glance
- Substrate of BCRP
- breast cancer resistance protein
Mechanism
- Substrate of BCRP
- breast cancer resistance protein
Magnitude / time course
- Inhibitors may raise or lower AUC by transporter role
- Kidney/liver/GI location determines direction
Exposure modifiers
- Transporter changes can alter exposure/distribution
Self-check
- Can changes in BCRP affect drug distribution as well as exposure?
Yes. - Which organ locations help determine BCRP interaction direction?
Kidney, liver and GI.
Drugs in this interaction (4)
All interaction examples · Open BCRP substrate in the interactive console ↗