BCRP inhibitor
- Inhibits BCRP
- breast cancer resistance protein
- Can change exposure of transporter substrates
- Direction depends on uptake vs efflux location
- Clinically important for selected narrow-index drugs
Interaction at a glance
- Inhibits BCRP
- breast cancer resistance protein
Mechanism
- Inhibits BCRP
- breast cancer resistance protein
Magnitude / time course
- Can change exposure of transporter substrates
Mechanism / modifiers
- Direction depends on uptake vs efflux location
- Clinically important for selected narrow-index drugs
Self-check
- What determines the direction of a BCRP inhibitor’s exposure effect?
Uptake versus efflux location. - For which drug group can BCRP interactions be especially important?
Selected narrow-index drugs.
Drugs in this interaction (5)
All interaction examples · Open BCRP inhibitor in the interactive console ↗