BCRP inhibitor
- Inhibits BCRP
- breast cancer resistance protein
- Can change exposure of transporter substrates
- Direction depends on uptake vs efflux location
- Clinically important for selected narrow-index drugs
Interaction at a glance
- Inhibits BCRP
- breast cancer resistance protein
Mechanism
- Inhibits BCRP
- breast cancer resistance protein
Magnitude / time course
- Can change exposure of transporter substrates
Mechanism / modifiers
- Direction depends on uptake vs efflux location
- Clinically important for selected narrow-index drugs
Self-check
- What usually happens to a sensitive BCRP substrate when a BCRP inhibitor is added?
Its exposure increases.
Drugs in this interaction (5)
All interaction examples · Open the interactive console ↗
