Atomoxetine + fluoxetine/paroxetine — CYP2D6
- Atomoxetine = sensitive CYP2D6 victim
- Fluoxetine/paroxetine block CYP2D6
- Use lower/slower atomoxetine dosing
- No extra effect in CYP2D6 poor metabolizers
Interaction at a glance
- Fluoxetine/paroxetine block CYP2D6
Mechanism
- Atomoxetine = sensitive CYP2D6 victim
- No extra effect in CYP2D6 poor metabolizers
Magnitude / time course
- Fluoxetine/paroxetine block CYP2D6
Management
- Use lower/slower atomoxetine dosing
Self-check
- How much can fluoxetine/paroxetine raise atomoxetine AUC?
About 6–8×.
- Which enzyme mediates this interaction?
CYP2D6.
Drugs in this interaction (3)
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