Atomoxetine + bupropion — CYP2D6
- Atomoxetine = sensitive CYP2D6 victim
- Bupropion inhibits CYP2D6
- May mimic CYP2D6 poor metabolism
- Start lower; titrate more slowly
- Watch HR/BP, insomnia, agitation
Interaction at a glance
- Bupropion inhibits CYP2D6
- Start lower; titrate more slowly
Monitoring
- Atomoxetine = sensitive CYP2D6 victim
- May mimic CYP2D6 poor metabolism
- Watch HR/BP, insomnia, agitation
Magnitude / time course
- Bupropion inhibits CYP2D6
Management
- Start lower; titrate more slowly
Self-check
- In Atomoxetine + bupropion, what is the approximate magnitude of the exposure change?
atomoxetine AUC ↑ ~5.1×
- Which enzyme or transporter is central to the Atomoxetine + bupropion interaction?
CYP2D6.
- Approximately how much does bupropion increase Atomoxetine AUC?
About 5.1×
Drugs in this interaction (2)
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