Atomoxetine + bupropion — CYP2D6
- Atomoxetine = sensitive CYP2D6 victim
- Bupropion inhibits CYP2D6
- atomoxetine AUC ↑ ~5.1×
- May mimic CYP2D6 poor metabolism
- Start lower; titrate more slowly
- Watch HR/BP, insomnia, agitation
Interaction at a glance
- Bupropion inhibits CYP2D6
- atomoxetine AUC ↑ ~5.1×
- Start lower; titrate more slowly
Monitoring
- Atomoxetine = sensitive CYP2D6 victim
- May mimic CYP2D6 poor metabolism
- Watch HR/BP, insomnia, agitation
Magnitude / time course
- Bupropion inhibits CYP2D6
- atomoxetine AUC ↑ ~5.1×
Management
- Start lower; titrate more slowly
Self-check
- How should atomoxetine be started and titrated with bupropion?
Start lower; titrate more slowly. - Which pathway mediates Atomoxetine + bupropion?
CYP2D6. - Approximately how much does bupropion increase Atomoxetine AUC?
About 5.1×
Drugs in this interaction (2)
All interaction examples · Open Atomoxetine + bupropion — CYP2D6 in the interactive console ↗