ALDH inhibitor
- Inhibits aldehyde dehydrogenase
- Acetaldehyde accumulates after alcohol
- Flushing, nausea, tachycardia + hypotension
- Disulfiram is the prototype
- Hidden alcohol exposure can still trigger symptoms
Interaction at a glance
- Inhibits aldehyde dehydrogenase
Mechanism
- Inhibits aldehyde dehydrogenase
- Disulfiram is the prototype
Mechanism / modifiers
- Acetaldehyde accumulates after alcohol
Clinical consequence
- Flushing, nausea, tachycardia + hypotension
- Hidden alcohol exposure can still trigger symptoms
Self-check
- What is the main clinical risk of ALDH inhibitor?
Flushing, nausea, tachycardia + hypotension.
Drugs in this interaction (1)
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