ALDH inhibitor
- Inhibits aldehyde dehydrogenase
- Acetaldehyde accumulates after alcohol
- Flushing, nausea, tachycardia + hypotension
- Disulfiram is the prototype
- Hidden alcohol exposure can still trigger symptoms
Interaction at a glance
- Inhibits aldehyde dehydrogenase
Mechanism
- Inhibits aldehyde dehydrogenase
- Disulfiram is the prototype
Mechanism / modifiers
- Acetaldehyde accumulates after alcohol
Clinical consequence
- Flushing, nausea, tachycardia + hypotension
- Hidden alcohol exposure can still trigger symptoms
Self-check
- What symptoms can occur after alcohol exposure during ALDH inhibition?
Flushing, nausea, tachycardia and hypotension. - What accumulates after alcohol with ALDH inhibition?
Acetaldehyde.
Drugs in this interaction (1)
All interaction examples · Open ALDH inhibitor in the interactive console ↗