Absorption (pH-dependent)
- Oral absorption changes with GI pH
- Direction depends on the drug/formulation
- PPIs, H2 blockers or antacids may alter exposure
- Enteric coatings can add formulation-specific effects
- Check whether interaction is clinically meaningful
Interaction at a glance
- Oral absorption changes with GI pH
Mechanism
- Oral absorption changes with GI pH
Magnitude / time course
- PPIs, H2 blockers or antacids may alter exposure
Monitoring
- Check whether interaction is clinically meaningful
Mechanism / modifiers
- Direction depends on the drug/formulation
- Enteric coatings can add formulation-specific effects
Self-check
- What should be checked before acting on a pH-dependent absorption interaction?
Whether it is clinically meaningful. - What determines the direction of a pH-dependent absorption effect?
Drug and formulation.
Drugs in this interaction (9)
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