Absorption (high-fat meal interaction)
- High-fat meals alter drug absorption
- Often increases exposure of lipophilic drugs
- Some agents instead have delayed/lower exposure
- Use the exact labeled meal instructions
- “With food” and “high-fat meal” are not equivalent
Interaction at a glance
- High-fat meals alter drug absorption
Mechanism
- High-fat meals alter drug absorption
Magnitude / time course
- Often increases exposure of lipophilic drugs
Exposure modifiers
- Some agents instead have delayed/lower exposure
- Use the exact labeled meal instructions
Mechanism / modifiers
- “With food” and “high-fat meal” are not equivalent
Self-check
- Are “with food” and “high-fat meal” instructions equivalent?
No. - Do high-fat meals always increase exposure?
No; some agents have delayed/lower exposure.
Drugs in this interaction (5)
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