Absorption (gastric emptying interaction)
- Gastric emptying changes oral absorption timing
- Slower emptying usually delays Tmax
- Effect on total AUC varies by drug
- GLP-1 drugs can matter for selected oral therapies
- Narrow-window oral drugs deserve extra attention
Interaction at a glance
- Gastric emptying changes oral absorption timing
Timing / washout
- Gastric emptying changes oral absorption timing
- Narrow-window oral drugs deserve extra attention
Magnitude / time course
- Effect on total AUC varies by drug
Mechanism
- Slower emptying usually delays Tmax
Mechanism / modifiers
- GLP-1 drugs can matter for selected oral therapies
Self-check
- Is the effect of gastric emptying on total AUC uniform?
No; it varies by drug. - How does slower gastric emptying usually affect Tmax?
Delays it.
Drugs in this interaction (9)
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