Absorption (acidic gastric pH required)
- Drug dissolves/absorbs best at low gastric pH
- Acid suppression can reduce bioavailability
- Magnitude depends on formulation + pKa
- PPIs can produce prolonged interaction
- Avoid or use an alternative when effect is large
Interaction at a glance
- Drug dissolves/absorbs best at low gastric pH
Mechanism
- Drug dissolves/absorbs best at low gastric pH
- PPIs can produce prolonged interaction
Management
- Acid suppression can reduce bioavailability
- Avoid or use an alternative when effect is large
Mechanism / modifiers
- Magnitude depends on formulation + pKa
Self-check
- How should a large acid-suppression absorption interaction be managed?
Avoid or use an alternative. - What determines an acidic-pH-dependent interaction’s magnitude?
Formulation and pKa.
Drugs in this interaction (9)
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