Absorption (acid suppression ↓)
- Higher gastric pH lowers drug absorption
- Typical victims need an acidic stomach
- PPIs usually have the strongest/longest effect
- H2 blockers/antacids may also matter
- Separate dosing may not fix sustained PPI effect
Interaction at a glance
- Higher gastric pH lowers drug absorption
Mechanism
- Typical victims need an acidic stomach
Mechanism / modifiers
- PPIs usually have the strongest/longest effect
- H2 blockers/antacids may also matter
Timing / washout
- Higher gastric pH lowers drug absorption
- Separate dosing may not fix sustained PPI effect
Self-check
- Does separating doses always resolve the sustained PPI effect on drug absorption?
No; separate dosing may not fix it. - Which acid suppressants usually have the strongest/longest absorption effect?
PPIs.
Drugs in this interaction (9)
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