Wake-promoting agents (eugeroics)
- Promote wakefulness without classic amp profile
- Modafinil/armodafinil are prototypes
- Narcolepsy, shift-work disorder, OSA sleepiness
- Less euphorigenic than amphetamine stimulants
- Headache, insomnia + rash
- Modafinil induces CYP3A and inhibits CYP2C19
- Does not replace treatment of sleep apnea
Class at a glance
- Promote wakefulness without classic amp profile
Members / distinctions
- Modafinil/armodafinil are prototypes
- Less euphorigenic than amphetamine stimulants
Pharmacology
- Modafinil induces CYP3A and inhibits CYP2C19
Clinical role
- Narcolepsy, shift-work disorder, OSA sleepiness
- Does not replace treatment of sleep apnea
Safety / monitoring
- Headache, insomnia + rash
Drugs in this class (4)
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