Transthyretin (TTR) stabilizers
- Bind tetrameric transthyretin
- Slow dissociation and amyloid formation
- Used for transthyretin amyloid cardiomyopathy
- Tafamidis/acoramidis are oral examples
- Slow progression rather than remove existing amyloid
- Earlier treatment preserves more function
Class at a glance
- Bind tetrameric transthyretin
Practical pearls
- Tafamidis/acoramidis are oral examples
Clinical role
- Slow dissociation and amyloid formation
- Used for transthyretin amyloid cardiomyopathy
Other clinical roles
- Slow progression rather than remove existing amyloid
- Earlier treatment preserves more function
Self-check
- What are Transthyretin (TTR) stabilizers used for?
Transthyretin amyloid cardiomyopathy. - Do TTR stabilizers remove existing amyloid?
No; they slow progression.
Drugs in this class (2)
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