Thionamides
- Inhibit thyroid-hormone synthesis
- Methimazole preferred for most hyperthyroid pts
- PTU favored in thyroid storm/early pregnancy
- Agranulocytosis is rare but dangerous
- Fever/sore throat → stop + check CBC urgently
- PTU has greater severe liver-toxicity risk
- They do not destroy preformed hormone
Class at a glance
- Inhibit thyroid-hormone synthesis
Practical pearls
- Methimazole preferred for most hyperthyroid pts
Members / distinctions
- Fever/sore throat → stop + check CBC urgently
- They do not destroy preformed hormone
Safety / monitoring
- PTU favored in thyroid storm/early pregnancy
- Agranulocytosis is rare but dangerous
- PTU has greater severe liver-toxicity risk
Self-check
- What is the main pharmacologic action of Thionamides?
Inhibit thyroid-hormone synthesis.
- What clinically distinguishes PTU within Thionamides?
greater severe liver-toxicity risk.
Drugs in this class (2)
All drug classes · Open the interactive console ↗
