Somatostatin analogs
- Suppress secretion through somatostatin receptors
- Octreotide/lanreotide: acromegaly + NET syndromes
- Pasireotide also treats selected Cushing disease
- GI upset + gallstones are common
- Glucose effects vary; pasireotide often worsens it
- Bradycardia can occur
- Long-acting depot formulations are common
Class at a glance
- Suppress secretion through somatostatin receptors
Members / distinctions
- Octreotide/lanreotide: acromegaly + NET syndromes
Clinical role
- Pasireotide also treats selected Cushing disease
- GI upset + gallstones are common
Other member distinctions
- Glucose effects vary; pasireotide often worsens it
- Bradycardia can occur
- Long-acting depot formulations are common
Self-check
- Which somatostatin analog often worsens glucose control?
Pasireotide. - What common adverse effects occur with somatostatin analogs?
GI upset and gallstones.
Drugs in this class (2)
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