Rifamycins
- Block bacterial RNA polymerase
- Core drugs for tuberculosis
- Rifampin is a very strong enzyme inducer
- Rifabutin has less induction burden
- Orange body fluids are expected
- Hepatotoxicity + many DDIs are major issues
- Never use rifampin monotherapy for active TB
Class at a glance
- Block bacterial RNA polymerase
Practical pearls
- Rifabutin has less induction burden
Other practical pearls
- Rifampin is a very strong enzyme inducer
Clinical role
- Core drugs for tuberculosis
- Orange body fluids are expected
- Never use rifampin monotherapy for active TB
Safety / monitoring
- Hepatotoxicity + many DDIs are major issues
Self-check
- What is the main pharmacologic action of Rifamycins?
Block bacterial RNA polymerase.
- What clinically distinguishes Rifabutin within Rifamycins?
less induction burden.
Drugs in this class (4)
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