Pulmonary vasodilators (prostacyclin pathway)
- Mimic or amplify prostacyclin signaling
- Potent pulmonary vasodilation + antiproliferation
- Epoprostenol is lifesaving in high-risk PAH
- Treprostinil has multiple delivery routes
- Selexipag is an oral IP-receptor agonist
- Headache, flushing + jaw pain are common
Class at a glance
- Mimic or amplify prostacyclin signaling
Pharmacology
- Selexipag is an oral IP-receptor agonist
Members / distinctions
- Potent pulmonary vasodilation + antiproliferation
- Treprostinil has multiple delivery routes
Safety / monitoring
- Epoprostenol is lifesaving in high-risk PAH
- Headache, flushing + jaw pain are common
Self-check
- Which prostacyclin-pathway drug is lifesaving in high-risk PAH?
Epoprostenol.
- What common adverse effects occur with prostacyclin-pathway drugs?
Headache, flushing, and jaw pain.
Drugs in this class (3)
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