Pharmacokinetic boosters
- Intentionally inhibit drug metabolism/transport
- Ritonavir/cobicistat are prototypes
- Raise exposure of a companion antiviral
- Creates major interaction burden with other drugs
- Booster has little/no target efficacy in some regimens
- Always review CYP3A/P-gp victim drugs
Class at a glance
- Intentionally inhibit drug metabolism/transport
Practical pearls
- Ritonavir/cobicistat are prototypes
Pharmacology
- Always review CYP3A/P-gp victim drugs
Members / distinctions
- Raise exposure of a companion antiviral
- Creates major interaction burden with other drugs
- Booster has little/no target efficacy in some regimens
Self-check
- How does Pharmacokinetic boosters work?
Intentionally inhibit drug metabolism/transport. - Which drugs are pharmacokinetic-booster prototypes?
Ritonavir and cobicistat.
Drugs in this class (2)
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