Orexin receptor antagonists
- DORAs reduce wake signaling rather than GABA
- Suvorexant/lemborexant/daridorexant
- Treat sleep-onset and/or maintenance insomnia
- Somnolence + next-day impairment can occur
- Avoid in narcolepsy
- Less respiratory suppression than BZDs, not zero
- CYP3A interactions matter
Class at a glance
- DORAs reduce wake signaling rather than GABA
Pharmacology
- CYP3A interactions matter
Clinical role
- Suvorexant/lemborexant/daridorexant
- Treat sleep-onset and/or maintenance insomnia
- Somnolence + next-day impairment can occur
Safety / monitoring
- Avoid in narcolepsy
- Less respiratory suppression than BZDs, not zero
Self-check
- When should Orexin receptor antagonists generally be avoided?
narcolepsy.
Drugs in this class (4)
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