Opioid antagonists (peripheral / PAMORAs)
- Block peripheral mu receptors in the gut
- Treat opioid-induced constipation
- Preserve central analgesia
- Methylnaltrexone/naloxegol/naldemedine
- Avoid with known/suspected GI obstruction
- Abdominal pain/diarrhea can be brisk
- CYP3A interactions matter for naloxegol
Class at a glance
- Block peripheral mu receptors in the gut
Pharmacology
- CYP3A interactions matter for naloxegol
Clinical role
- Treat opioid-induced constipation
- Preserve central analgesia
- Methylnaltrexone/naloxegol/naldemedine
Safety / monitoring
- Avoid with known/suspected GI obstruction
- Abdominal pain/diarrhea can be brisk
Self-check
- How does Opioid antagonists (peripheral / PAMORAs) work?
Block peripheral mu receptors in the gut. - When should PAMORAs be avoided?
Known or suspected GI obstruction.
Drugs in this class (4)
Opioid antagonists (peripheral / PAMORAs) prescription history
Animated chart of estimated U.S. prescriptions per year, Constipation meds (1900–2026). PAMORAs highlighted from 2008.
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