Opioid antagonists (peripheral / PAMORAs)
- Block peripheral mu receptors in the gut
- Treat opioid-induced constipation
- Preserve central analgesia
- Methylnaltrexone/naloxegol/naldemedine
- Avoid with known/suspected GI obstruction
- Abdominal pain/diarrhea can be brisk
- CYP3A interactions matter for naloxegol
Class at a glance
- Block peripheral mu receptors in the gut
Pharmacology
- CYP3A interactions matter for naloxegol
Clinical role
- Treat opioid-induced constipation
- Preserve central analgesia
- Methylnaltrexone/naloxegol/naldemedine
Safety / monitoring
- Avoid with known/suspected GI obstruction
- Abdominal pain/diarrhea can be brisk
Self-check
- What is the main pharmacologic action of Opioid antagonists (peripheral / PAMORAs)?
Block peripheral mu receptors in the gut.
Drugs in this class (4)
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