Nitrates / nitrites (organic)
- Release nitric oxide → ↑ cGMP
- Venodilation predominates at usual doses
- Rapid relief/prevention of angina
- Headache + hypotension are common
- Continuous exposure causes tolerance
- PDE5 inhibitors are contraindicated partners
Class at a glance
- Release nitric oxide → ↑ cGMP
Safety / monitoring
- PDE5 inhibitors are contraindicated partners
Members / distinctions
- Venodilation predominates at usual doses
- Rapid relief/prevention of angina
- Continuous exposure causes tolerance
Practical pearls
- Headache + hypotension are common
Self-check
- What common adverse effects occur with organic nitrates?
Headache and hypotension.
- Which drug class is contraindicated with nitrates?
PDE5 inhibitors.
Drugs in this class (4)
All drug classes · Open the interactive console ↗
