Methylxanthines
- Adenosine antagonism + PDE inhibition
- Caffeine and theophylline are key examples
- Stimulate CNS; theophylline bronchodilates
- Narrow index is important for theophylline
- CYP1A2/smoking strongly affect clearance
- Toxicity: tremor, arrhythmia + seizures
Class at a glance
- Adenosine antagonism + PDE inhibition
Practical pearls
- Caffeine and theophylline are key examples
Pharmacology
- Stimulate CNS; theophylline bronchodilates
- CYP1A2/smoking strongly affect clearance
Other practical pearls
- Narrow index is important for theophylline
Safety / monitoring
- Toxicity: tremor, arrhythmia + seizures
Self-check
- What do Methylxanthines stimulate?
CNS; theophylline bronchodilates.
Drugs in this class (3)
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