Leukotriene modifiers
- Oral anti-leukotriene asthma/allergy drugs
- Montelukast is the major member
- Less effective than ICS for asthma control
- Useful with allergic rhinitis/exercise symptoms
- Convenient oral option in selected patients
- Montelukast has boxed neuropsychiatric warning
- Not a rescue bronchodilator
Class at a glance
- Oral anti-leukotriene asthma/allergy drugs
Members / distinctions
- Montelukast is the major member
- Less effective than ICS for asthma control
Clinical role
- Useful with allergic rhinitis/exercise symptoms
- Convenient oral option in selected patients
- Not a rescue bronchodilator
Practical pearls
- Montelukast has boxed neuropsychiatric warning
Pearls
- Weaker ICS add-on than a LABA
- Rare EGPA reported with montelukast and zafirlukast
Self-check
- When are Leukotriene receptor antagonists especially useful?
Allergic rhinitis/exercise symptoms. - What distinguishes Montelukast?
Boxed neuropsychiatric warning.
Drugs in this class (3)
Leukotriene modifiers prescription history
Animated chart of estimated U.S. prescriptions per year, Asthma/COPD meds (1924–2026). Leukotriene modifiers highlighted from 1996.
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