Immunosuppressants (calcineurin inhibitors / CNIs)
- Tacrolimus/cyclosporine block calcineurin
- ↓ T-cell IL-2 transcription
- Core transplant immunosuppression
- Nephrotoxicity + hypertension are major limits
- Narrow therapeutic index → TDM
- CYP3A/P-gp DDIs can be dramatic
Class at a glance
- Tacrolimus/cyclosporine block calcineurin
Pharmacology
- CYP3A/P-gp DDIs can be dramatic
Practical pearls
- ↓ T-cell IL-2 transcription
- Narrow therapeutic index → TDM
Safety / monitoring
- Core transplant immunosuppression
- Nephrotoxicity + hypertension are major limits
Self-check
- What is the main pharmacologic action of Immunosuppressants (calcineurin inhibitors / CNIs)?
Tacrolimus/cyclosporine block calcineurin.
Drugs in this class (4)
All drug classes · Open the interactive console ↗
