Immunosuppressants (antimetabolites)
- Inhibit lymphocyte nucleotide synthesis
- Mycophenolate/azathioprine are key examples
- Used in transplant + autoimmune disease
- Cytopenias and infection are major risks
- GI toxicity is common with mycophenolate
- Pregnancy risk is especially important for MMF
Class at a glance
- Inhibit lymphocyte nucleotide synthesis
Practical pearls
- Mycophenolate/azathioprine are key examples
Clinical role
- Used in transplant + autoimmune disease
Safety / monitoring
- Cytopenias and infection are major risks
- GI toxicity is common with mycophenolate
- Pregnancy risk is especially important for MMF
Self-check
- What is the main pharmacologic action of Immunosuppressants (antimetabolites)?
Inhibit lymphocyte nucleotide synthesis.
- What key adverse effect/risk occurs with Immunosuppressants (antimetabolites)?
GI toxicity is common with mycophenolate.
Drugs in this class (5)
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